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10.1016/j.cmet.2019.08.021 15 ChenY.-m.LiuY.ZhouR.-f.ChenX.-l.WangC.TanX.-y.et al (2016)

Other sweeteners could be used for a placebo like aspartame or fructose to fulfill the non-allulose control

Cycle Length and Continuous Use Clinical trials have safely used AOD-9604 for durations ranging from single doses to 24 weeks of continuous daily administration

It may mean the pace of escalation is too aggressive, the patients nutrition is not keeping up, or constipation and hydration need to be addressed first