While endogenous GLP-1 and all peptide GLP-1 agonists bind to the orthosteric site on the extracellular surface and transmembrane domain of the GLP-1 receptor, orforglipron occupies a distinct allosteric pocket formed primarily by transmembrane helices 1, 2, 3, and 7, along with extracellular loop 2
Until then, there is no getting around the fact that unless you have diabetes, only the rich can afford them (of course, the price may seem less exorbitant once you factor in alternative costs - programs like Jenny Craig and even apps like Noom can cost hundreds of dollars a month if you sign up for all the bells and whistles)
Ethnicity was not recorded in our patient data system, but the majority of patients in our study were Caucasian, which hampers assertions regarding a switch to semaglutide from other GLP-1 analogues in other ethnicities
These findings were interpreted as indicative of a possible correlation rather than a definitive causal relationship, reinforcing the need for further controlled investigations to clarify underlying mechanisms