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(1998) 105:22S6S
GPX3, a key member of the GPX family, has predominantly been investigated within oncology [23,24,25], but it has also been shown to play essential roles in pathological processes such as inflammation, fibrosis, metabolic homeostasis and insulin resistance [26,27,28]
GLP-1RAs reduce the expression of cholesterol synthesis and bile acid synthesisassociated genes by inhibiting SREBP-2 in HepG2 cells treated with PA To investigate whether SREBP-2 inhibition mediated by GLP-1RAs affects the expression of cholesterol metabolism-related genes, HepG2 cells were transfected with SREBP-2 siRNA for 24 hours, followed by PA and GLP-1RA treatments
Gut microbiota perturbations have been postulated to contribute to pathogenesis of endometriosis via the regulation of inflammatory processes and estrogen metabolism (reviewed in 65 ), and gut permeability is increased in patients with endometriosis 66 which may contribute to the systemic nature of this condition (reviewed in 67 )
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