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Nausea and vomiting are also known side-effects of the medication that was approved in the United States in 2017 for Type 2 diabetes, followed by its approval by Health Canada a year later

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No published pharmacokinetic studies directly measure this interaction, making it impossible to quantify safe spacing or dosing adjustments

For increased patient safety in APAP consumption, the FDA has worked to mitigate APAP hepatotoxicity by legislating regulations to limit prescription combination drug products to have no more than 325 mg of APAP per dosage unit and have urged healthcare providers to cease prescribing combination drug products with more than 325 mg of APAP per tablet