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When switching from a longer-acting medication (semaglutide) to a shorter-acting one (tirzepatide), or vice versa, the gastric emptying pattern shifts, potentially altering absorption of concurrent oral medications

One potential mechanism that could indirectly affect contraceptive effectiveness is semaglutides impact on digestion

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Key safety considerations include pre-treatment endocrine baseline assessment, monitoring of serum IGF-1 within physiological reference ranges, evaluation of glucose metabolism and insulin sensitivity, and awareness of potential fluid retention