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Additionally, ER stress-triggered necroptosis is mediated by the recruitment of cathepsin B-associated activating protein 1 (AP-1) [146]

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Nat Rev Dis Primers (2021) 7(1):86

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Tolerance is a physiological state characterized by a reduced response to a drug after repeated administration (i.e., a higher dose of a drug is required to produce the same effect that was once obtained at a lower dose)

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If B12 levels are borderline, additional tests such as methylmalonic acid (MMA) or homocysteine may be helpful

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