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FDA granted the applicant 510(k) clearance for the aprevo Cervical ACDF System on November 15, 2024, with separate indications for the aprevo Cervical ACDF system and the aprevo Cervical ACDF-X system (with and without CAM)

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From earlier work focused on muscular dystrophy conducted with former Penn Dental Medicine faculty member Elizabeth Barton, now at the University of Florida, the researchers believed that a particular form of IGF, a precursor of the protein that includes a separate component known as an e-peptide, was likely to stimulate regeneration better than mature IGF-1 that lacked the peptide