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doi: 10.7554/ELIFE.100535 36 KuricESeironPKrogvoldLEdwinBBuanesTHanssenKFet al

This brief duration of action limits its therapeutic utility in its natural form, necessitating the development of longer-acting GLP-1 receptor agonists that can provide sustained clinical benefits with less frequent dosing

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Clinical trials reveal that 10-15% of participants taking GLP-1 medications like Wegovy or Mounjaro qualify as non-responders, losing less than 5% of their body weight