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Recent studies have highlighted lipid droplet accumulation in ApoE4 carriers, especially within phagocytic cells

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This perspective is bolstered by the observation that interventions developed for neurodegenerative diseases sometimes intersect with tinnitus symptomatology, as seen in a meta-analysis of gamma-frequency stimulation for AD, which, while aiming to improve cognition, was associated with an increased risk of inducing tinnitus as a side effect (Ang et al., 2025)