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Ferroptosis primarily occurs through the L-cystine/glutamate antiporter (system Xc-)/glutathione (GSH)/GSH peroxidase 4 (GPX4) pathway, the GTP cyclohydroxylase-1 (GCH1)/tetrahydrobiopterin (BH4) pathway, the dihydroorotate dehydrogenase (DHODH) pathway, the O-acyltransferase 1/2 (MBOAT1/2)-monounsaturated fatty acid (MUFA) pathway, the nuclear factor-erythroid 2-related factor 2 (Nrf2) pathways, the mevalonate pathway and the apoptosis-inducing factor mitochondria-associated 2 (AIFM2, also known as FSP1 and referred to as FSP1 throughout) pathway-mainly the FSP1-coenzyme Q10 (CoQ10)-NAD(P)H, FSP1-vitamin K (VK)-NAD(P)H and FSP1-endosomal sorting complex, required for transport (ESCRT)-III pathways (Fig
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Perry RJ, Peng L, Barry NA, Cline GW, Zhang D, Cardone RL, Petersen KF, Kibbey RG, Goodman AL, Shulman GI
This leads to weight loss and can help individuals maintain a healthier weight
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