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At the regulatory level, SIRT1 expression is influenced by transcriptional, epigenetic, post-transcriptional, and metabolic mechanisms

Finally, In a recent meta-analysis on 56,004 patients from 7 CVOTs (68.9% patients with established cardiovascular disease), GLP-1RAs reduced the risk of MACE by 13%, of cardiovascular death by 12%, of all-cause mortality by 11%, of non-fatal stroke by 16%, of hospitalization for heart failure by 9%, of macroalbuminuria by 24% [13]

S., Metghalchi, Y., Tavakoli, R., Ziaei Rahimabadi, R., & Ghaheri, M

Effect of exenatide on the cardiac expression of adiponectin receptor 1 and NADPH oxidase subunits and heart function in streptozotocin-induced diabetic rats