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As the disease progresses, patients will likely require adjustments in their symptomatic medication regimens, potentially confounding the assessment of disease-modifying effects and requiring larger and longer studies

The 15mg dose in SURMOUNT-1 produced the 22.5% average body weight reduction, but this was measured at week 72, so the full effect takes time

The impact of creatine supplementation associated with resistance training on muscular strength and lean tissue mass in the aged: a systematic review and meta-analysis

So now with those other outcomes, like you said, Medicare is starting this pilot program to understand if these medications lead to overall cost savings