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The BBB is a major obstacle for many drugs, especially large molecules like peptides, in reaching the central nervous system

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Crucially, PCOS affects women in both urban and rural areas, highlighting the fact that it is a systemic condition influenced by biological susceptibility interacting with environmental and nutritional factors rather than a lifestyle disorder exclusive to particular social groups ( The following sections examine each micronutrients molecular targets and clinical relevance, integrating evidence from observational studies and randomized trials with mechanistic data from cellular and animal models to clarify their potential to modulate key pathways underlying insulin resistance, hyperandrogenism, oxidative stress, and inflammation in PCOS