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Core strengthening, structured exercise programs, and professional physical therapy remain the most effective long-term strategies for improving function and reducing recurrence

NOS-3 also functions alongside GLD-2 to regulate GLD-1 accumulation in the proximal progenitor zone, while the exact mechanism remains unclear (Hansen et al., 2004a

The N-terminal region typically contains the signal peptide, which is required for secretion of the mature effector protein from the pathogen into the host (Presti et al., 2015), as well as the translocation domain, which is required for the correct localisation of the effector into the host cell (Irieda et al., 2019)

CBT-I has also shown effectiveness across various age groups