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The inclusion/exclusion process is shown in Fig

Consequently CJC 129 without DAC is designed to provide a GHRM-like stimulation around the clock with increased amplitude and longer stimulation, (28 minutes instead of 8-12 of sermorelin), maintaining the natural pulsatile stimulation of the pituitary without decreasing secretion as observed in CJC with DAC

Therefore, understanding the endogenous expression profile of IGF-1 during tendon healing is crucial for determining the optimal timing of exogenous IGF-1 administration

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