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Indeed, a 2019 literature review discussed berberines potential for antitumor effects against a few types of cancer, and a more recent review from 2024 highlighted its ability to support chemotherapy.13 49 At this time, the most extensive research on berberine has revolved around its impacts not on cancer but on diabetes and cholesterol management, so those are the health concerns for which the supplement is most likely to yield benefits

Copper-metabolism disorders: a conceptual contraindication The clearest safety concern involves disorders of copper handling

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Phytic acid can range from 2.9 to 7.9 g/kg and reduces the bioavailability of minerals such as Fe, Zn, and Ca, although treatments such as soaking, germination, fermentation, and extrusion significantly decrease its content (Thakur, 2021