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It also contributes to blood glucose control by stimulating insulin secretion only when blood sugar is elevated

Seek urgent care for chest pain, fainting, or severe allergic reactions

Common reactions include: Bloating and gas Diarrhea Decreased appetite Metallic taste in mouth A concern with long-term metformin use is vitamin B12 deficiency [20]

Effect of weight loss and regain on adipose tissue distribution, composition of lean mass and resting energy expenditure in young overweight and obese adults