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For substance-use disorders, early evidence suggested that GLP-1RAs might reduce alcohol and opioid cravings by influencing dopamine pathways involved in reward processing
(21) After 52 weeks, there was no significant difference in P1NP between semaglutide and placebo groups, with an estimated difference of 3.8 g/L (95% CI: 5.6-13.3, p = 0.418)
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