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The LR3 (Long R3) modification is a clever bit of bioengineering that dramatically extends its half-life and, crucially, prevents it from being bound and rendered inactive by insulin-like growth factor-binding proteins (IGFBPs) in the bloodstream

Synthetic exendin-4 became exenatide, marketed as Byetta, and in 2005, it became the first GLP-1 receptor agonist approved by the FDA for the treatment of type 2 diabetes

Step 4: Swirl gently (never shake) Once all the water is in the vial, remove the syringe and set it aside for disposal

The Wegovy pill brings one of the UK's most talked-about weight management treatments into a once-daily tablet