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Actions in the HPA axis kick-start the bodys natural stress reaction system, commonly referred to as the NeuroEndoMetabolic (NEM) stress response

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The primary available study, Naessen et al

Considerations for specific populations: Individuals with a personal or family history of medullary thyroid cancer or multiple endocrine neoplasias should avoid these medications Pregnant or nursing women are advised not to use semaglutide or Zepbound Those with a history of pancreatitis, certain thyroid cancers, or a slow digestive system should exercise caution While Zepbound may potentially present more frequent or severe side effects due to its higher potency, the overall risk profile is similar to that of semaglutide