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In reviews of the literature published between 1999 and 2007, Daly-Youcef [4] and Andrs E [19] concluded that orally administered vitamin B12 provided effective treatment for adult and elderly patients with deficiencies, although they highlighted that further studies were needed to determine its effectiveness in patients with severe neurological symptoms
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[DOI] [PMC free article] [PubMed] [Google Scholar] 29.Laurberg P., Pedersen K.M., Vestergaard H., Sigurdsson G
Another study showed that in JHU-083-treated cancer cell allograft models, an increase in nutrient levels and oxygen and a decrease in the acidity of the TME resulted in T-cell-mediated tumor suppression 145 , whereas another study demonstrated the effects of JHU-083 on myeloid-derived suppressor cells (MDSCs) and TAMs 150
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