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10.3390/molecules28155667 96 NilssonM

Still, one stands out called the salvage pathway because it is the most abundant in mammalian cells (the others are called the Preiss-Handler pathway, in which NAD+ is synthesized from nicotinic acid, and the de novo synthesis pathways, which starts from tryptophan)

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These mediators contribute to central appetite control and neuronal plasticity, while FGF21, especially stimulated by resistance exercise, further modulates hypothalamic circuits and promotes the browning of white adipose tissue, enhancing thermogenesis (45)