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I dont believe GLP-1s are the only answerbut they are one option

Specifically, it acts as a single peptide that simultaneously activates three receptors involved in metabolic regulation: the glucose-dependent insulinotropic polypeptide receptor (GIPR), the glucagon-like peptide-1 receptor (GLP-1R), and the glucagon receptor (GCGR)

We found that the HTR4 mRNA level was reduced in both the liver and WAT of HFD-fed mice

Conclusion The intersection of semaglutide therapy for type 2 diabetes and obesity with the administration of antibiotics represents a nuanced aspect of modern healthcare that demands careful consideration and a nuanced approach