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Any significant or persistent change in stool color, particularly when paired with other symptoms, warrants a discussion with your gastroenterologist to rule out underlying conditions and ensure timely treatment

The authors emphasize that the study does not establish a direct causal relationship between weight loss and improved mental health, noting that the connection between the medications, weight reduction, and mental health is likely complex

The mean duration of follow-up varied among the studies, ranging from 6 to 48 months, with an average follow-up period of 39 months

Based on leaky phenotypes of secretin gate mutant strains, this structure appears to restrict the size of the secretin pore to that of typical porins, preserving the outer membranes barrier function 22,23,24,25