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doi:10.3389/fnut.2022.1082097 Virmani MA, Cirulli M

The presence of large spindled and/or epithelioid melanocytes is the defining histopathologic feature of Spitz nevi

These reactions occur because the needle creates a small wound and the medication itself can trigger temporary local inflammation

These mechanisms collectively promote significant weight loss, with clinical trials demonstrating average reductions of 1522% of body weight over 72 weeks, though individual results vary by dose and patient factors