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N-acetylcysteine (NAC) may benefit patients with severe oxidative damage (e.g., diabetic nephropathy) by replenishing glutathione ( Given the variability in individual redox status, future strategies should consider measuring OS biomarkers (e.g., MDA, SOD, GPx) to identify patients who may benefit from supplementation
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Glutathione not only detoxifies ROS, but also modulates antioxidant enzymes
Because this is still an investigational compound, we frame the science honestly: what is genuinely studied, and what remains unknown
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