glp 1 impact on bariatric surgery Choosing Between Weight Loss Medications and GLP-1 medications changed the conversation

doi: 10.3389/fnut.2024.1385518 250 TanakaM.Szab.VcseiL

Glutathione Depletion: A Modern Epidemic Glutathione levels decline with age - typically by 1015% per decade after age 20 - and are further depleted by: *Chronic illness and autoimmune conditions *Environmental toxin exposure (heavy metals, pesticides) *Poor nutrition (insufficient cysteine, glycine, glutamate precursors) *Chronic psychological stress *Alcohol consumption *Certain medications (acetaminophen, chemotherapy agents) *Intense physical exercise without adequate recovery Given that thyroid disease prevalence increases with age and is associated with chronic immune activation, the parallel decline in glutathione levels is not coincidental - it is mechanistically significant

Moreover, GLP-1 receptors interact with various neurotransmitter systems such as serotonin, dopamine, and glutamate, which are essential for mood regulation and may contribute to the onset of depression and other psychological disorders [82]

It works by mimicking the effects of a hormone called GLP-1, which is released by the gut after eating