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Furthermore, the restored gut microbiota composition, particularly the enrichment of prevotella (a known butyrate producer), suggests a compelling mechanism for the ameliorated oxidative stress and potential enhancement of gut and BBB integrity [39]

Neuronal GPX4 is downregulated after SCI, and ferroptosis inhibitors SRS 16-86 and DFO both prevent the reduction of GPX4 and improve the survival rate of neurons in the injured spinal cord to repair SCI-associated motor dysfunction