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190 Piceatannol (PIC), another natural arginase inhibitor, can effectively inhibit TGF-1 /TGF- receptor type 1 (TGF-R1) signaling pathway, limit M2-type macrophage polarization to regulate TME and inhibit CRC progression and metastasis

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It is dose-dependent, more common during loading phase, and diminishes as tachyphylaxis develops over the first 710 days

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