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A total of 137 patients (47.6%) discontinued their medication due to cost or insurance-related issues (including insurance denial, expiration of manufacturer discount coupon, or out-of-pocket cost being unaffordable), 42 (14.6%) due to side effects, 34 (11.8%) due to medication shortages, seven (2.4%) due to switching to a compounded medication and five (1.7%) due to unsatisfactory weight loss

Then, mice were injected with either vehicle or the drugs as indicated, and the saccharin bottle was replaced by a water bottle