Tirzepatides added GIP receptor activation may amplify the insulin-sensitizing effect beyond what semaglutide achieves alone, which matters specifically when cortisol is driving the insulin resistance
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Discontinuation Rates Retatrutide 12 mg: 18.2% discontinued Retatrutide 9 mg: 12.2% Placebo: 4% [9] For comparison: Semaglutide: 4.5% discontinued [10] Tirzepatide: ~7% discontinued at highest dose [11] That 18.2% discontinuation rate for Retatrutide is strikingly high
