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Semaglutide is broken down through proteolytic degradation rather than being excreted unchanged in urine, so drinking extra water will not speed up the clearance process

10.1016/j.toxicon.2021.01.020 8 BarcikW.BoutinR

Another study, the EXAMINE trial, investigated alogliptin medication in individuals with Type 2 diabetes who had experienced acute coronary syndrome and revealed no increase in major adverse cardiovascular events