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Brown Nancy

CYP3A4 and CYP3A5: the crucial roles in clinical drug metabolism and the significant implications of genetic polymorphisms

The Lancet Diabetes & Endocrinology, 7(7), 528-539

As a long-acting IGF-1 analog, the compound represents a research subject in the broader field of peptide stability engineering specifically the use of structural modifications including N-terminal extension and amino acid substitution strategies to extend peptide half-life and modify peptide-binding protein interactions compared to native IGF-1 sequences