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In a separate announcement also on Tuesday, Novo touted nearly 20% weight loss after 24 weeks for its United Biotechnologypartnered triple-G agonist

71% noticed that their self-esteem had improved, and more than 2/3rds of patients felt they had a more positive body image after losing weight

The brain pathway may be more significant than the endocrine route for the physiological effects of GLP-1, especially regarding insulin release, but the endocrine route becomes more pronounced with bigger meals and more L-cell activation (Deacon 2019)