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Within COVID-19 patients, serum IL-6 and IL-10 levels are positively correlated with disease severity, indicating inflammatory cytokines might be an indicator for disease prognosis (Han et al., 2020)
Some of the most common are based around comfort as opposed to physiology
The bedtime timing matters because the goal is to amplify a pulse that would otherwise occur naturally during deep sleep, not to introduce a daytime pulse that conflicts with normal pituitary rhythms
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