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[] When comparison to a placebo, NAC significantly enhanced performance as determined by the Clinical Global Impression-Severity (CGI-S) scales, yet did not improve on additional functioning measures, such as the Streamlined Longitudinal Interview Clinical Evaluation from the Longitudinal Interval Follow-up Evaluation (SLICE-LIFE) or the Social and Occupational Functioning Assessment Scale and Longitudinal Interval Follow-up Evaluation-Range of Impaired Functioning Tool

However, it did significantly reduce the decrease in motor nerve conduction velocity and paw intraepidermal fiber density observed in diabetic mice through the activation of extracellular signal-regulated kinase (ERK) signaling [81]

Jena, Sodium butyrate, a HDAC inhibitor ameliorates eNOS, iNOS and TGF-1-induced fibrogenesis, apoptosis and DNA damage in the kidney of juvenile diabetic rats

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