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The protective effect of quercetin on macrophage pyroptosis via TLR2/Myd88/NF-B and ROS/AMPK pathway

For instance, activated JNK can phosphorylate c-Jun, a transcription factor, and together, they can regulate the expression of genes involved in apoptosis and inflammation [127, 128]

Consistent with this notion, under conditions of cysteine starvation, the GSH-catabolizing enzyme CHAC1 mobilizes cysteine to sustain mitochondrial Fe-S cluster biogenesis and respiratory function