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In post-marketing surveillance and clinical practice, some patients have reported musculoskeletal symptoms, including back pain, while taking these medications

Furthermore, the deletion of Bmal1 in the brain induced apoE expression (inhibiting, e.g., astrocytic clearance of A [73]), potentially elucidating how circadian disruption may increase A burden in the brain

Sertraline's action occurs primarily in the central nervous system through inhibition of the serotonin transporter protein