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It supports insulin sensitivity, may influence how the body handles dietary fat, and activates receptors in brain regions involved in appetite control

Each major muscle group should receive direct training at least twice weekly, which research shows produces superior hypertrophy compared to once weekly training

For example, INT-777 and MN6, TGR5 selective agonists, stimulated GLP-1 secretion and improved insulin sensitivity in diet-induced obesity (DIO) mice [180, 181]

60 However, in humans, early studies demonstrated that GLP-2 administration for five weeks increased spinal BMD in people with short bowel syndrome, 62 but had limited overall bone benefits