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S., Li, Y., Rimm, E

Founded in 1921 by four renowned physicians with a vision of providing outstanding patient care based upon the principles of cooperation, compassion and innovation, Cleveland Clinic has pioneered many medical breakthroughs, including coronary artery bypass surgery and the first face transplant in the United States

These receptors are activated when peptide ligands interact with extracellular receptor domains, producing conformational changes that initiate intracellular signaling