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Many patients achieve significant and lasting weight loss when these medications are combined with lifestyle changes

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The 12 week phase 1b clinical trial for patients with type 2 diabetes from December 18, 2018 to December 28, 2020 showed that the three high-dose groups of Retatrutide were significantly better than the placebo control group in reducing blood sugar and glycosylated hemoglobin (HbA1c), and showed a dose related weight loss effect

They do not respond to other G protein-coupled receptor (GPCR)-activating hormones, such as GIP (glucose-dependent insulinotropic polypeptide) or glucagon