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In a randomized controlled trial (RCT) evaluating the weight change using semaglutide, it was also found that after discontinuation of semaglutide, the patients gained weight significantly as well as a significant increase in blood pressure [17], which was a reminder that weight regain may have some adverse effects

Semaglutide tends to work best when it is part of a bigger plan that also supports eating habits, physical activity and follow-up care

Heterogeneity and sensitivity analyses: We assessed heterogeneity using the I2 statistic and Cochrans Q test and explored sources of variability through prespecified subgroup analyses (e.g., by tirzepatide dose, comparator type, baseline BMI, presence of diabetes)

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