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Discussion In this systematic review and meta-analysis we summarised and synthesised the most up-to-date data from RCTs of once-weekly tirzepatide in individuals with type 2 diabetes

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For the efficacy estimand, the LSM change in HbA1c from baseline at week 52 as the primary endpoint was 2.24%, 2.43%, and 2.58% with tirzepatide 5, 10, and 15 mg, respectively, versus 1.44% with insulin glargine