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Gallbladder problems (such as gallstones or inflammation of the gallbladder) have been reported with GLP-1 receptor agonists

Although it has not been compared in any other studies, the efficacy with which liraglutide lowers alcohol consumption is greater than the corresponding efficacy of Ex4 in non-human primates (Thomsen et al., 2019), indicating differences between these GLP-1R agonists

Xie ZQ, Li HX, Tan WL, et al

The lower bioavailability actually works in favor here, as the body receives the active compound more gradually throughout the day rather than in a single bolus that can overwhelm GLP-1 receptors in the gut