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The intrinsic ability of cancer cells to tolerate and recover from this DNA damage can stem from several pathways, including anti-apoptotic mechanisms, cell cycle arrest, DNA damage repair (DDR) and nucleotide metabolism, the oxidative/electrophilic stress response to free radicals, autophagy
As of 2024, clinical trials have not shown a signal for increased thyroid cancer risk with Zepbound, but ongoing surveillance continues
Statistical analysis Statistical analyses were conducted via GraphPad Prism 8 (GraphPad Software, San Diego, CA)
These two classes of cytosolic GSTs have undergone species-specific gene expansion to a great extent [41, 64, 65]
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