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doi: 10.1016/j.ajpath.2016.06.003

It implicates that microbiota-derived SCFA facilitates histone crotonylation in the colon at least in part via HDACs

Therefore, when curcumin and lauric acid liposomal gels are combined for therapy, there is a notable decrease in IL-1 and TNF- levels by around 1.9 and 2.5 times, indicating its effectiveness in treating acne [332]

Perhaps most striking is its influence at the gene expression level: genome-wide profiling has shown that GHK-Cu affects approximately 4,000 human genes, shifting patterns associated with tissue damage and ageing toward profiles characteristic of healthier, younger tissue