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10.1371/journal.pbio.3000998 87 RaiP.KumarM.SharmaG.BarakP.DasS.KamatS

However, their effectiveness may diminish as the body adjusts to them

These dysfunctions may arise from impaired pyruvate dehydrogenase (PDH) function identified in muscle cells (390) and serum (184), as well as reduced plasma coenzyme Q10 (CoQ10) levels in ME/CFS blood and plasma (372, 391) that is inversely associated with fatigue severity (391)