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The role of isovalerate in psychiatric disorders is however uncertain, and there are some studies evidencing that an increase of this component is directly correlated with depression and cortisol levels, being able to interfere with synaptic neurotransmitter release after crossing the BBB [259]
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The expression level of the gene in the wild-type (CO23) or resistant (CO23RFK and CO23RFLC) strains, treated or untreated with FLC or MCFG, are represented as n-fold increase or decrease relative to the level of the untreated control strain (CO23)
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