18 BLM induced the upregulation of Col12, Col31 and Col4a2 mRNA expression compared with control, and FOXO4DRI repressed BLMinduced upregulation of the above genes similar to PFD group (Figure 1E)
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Based on recent research, autoimmune destruction of early hematopoietic stem cells may be the cause of AAA, a rare condition that manifests as bone marrow failure syndrome and might be regarded as a clonal disorder of hematopoietic stem cells (136)
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