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When to Delay Dose Escalation Hold your current retatrutide dose and don't escalate if you experience: Persistent nausea or vomiting (more than 3 days after injection) Severe constipation or diarrhea Significant injection site reactions Rapid weight loss (more than 3-4 lbs/week consistently) Signs of dehydration from GI symptoms It's acceptable to remain at a dose longer than 4 weeks if needed

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